FREDERIC COMTE, ISM / SCIENCE PHOTO LIBRARY FREDERIC COMTE, ISM / SCIENCE PHOTO LIBRARY
Paget's disease. Coloured bone scans (scintigrams) of the skeleton of an 83 year old patient with Paget's disease (left from the front, right from the back). These scans show the mineral density of bone, ranging from blue (least dense) through yellow to red (most dense). In Paget's disease the normal process of bone formation is disrupted, causing affected bones to thicken, weaken, and become deformed. The disease usually affects only limited areas of the skeleton, especially the skull, pelvis, clavicle, vertebrae and leg bones. The worst affected area in this individual is the pelvis. Paget's disease often causes no symptoms and is typically discovered by accident. The cause is unknown.
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