FRANCIS LEROY & CLEMENT DOMERGUE, BIOCOSMOS / SCIENCE PHOTO LIBRARY FRANCIS LEROY & CLEMENT DOMERGUE, BIOCOSMOS / SCIENCE PHOTO LIBRARY
White blood cell movement. Animation showing a white blood cell moving from a blood vessel into the surrounding tissue, a process known as extravasation or diapedesis. The process starts with the white blood cell rolling along the endothelial cells that line the blood vessel. This step is mediated by receptors on the endothelial cells that attach to the white blood cell, slowing it down. When it reaches a gap between endothelial cells the white blood cell extends psuedopodia and squeezes between the cells and into the interstitial fluid. This is characteristic of the inflammatory response, which occurs at the site of an injury. The cells leave the blood for the surrounding tissues so that they can destroy any invading organisms that may be present.
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