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Osteopetrosis of the spine, X-ray

Osteopetrosis of the spine, X-ray

C023/4512

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Credit

PR JEAN-DENIS LAREDO - ISM / SCIENCE PHOTO LIBRARY PR JEAN-DENIS LAREDO - ISM / SCIENCE PHOTO LIBRARY

Caption

Osteopetrosis of the spine. X-ray of a normal lumbar spine (right) compared to that of a patient with osteopetrosis (left). Osteopetrosis, also known as marble bone disease, is a rare inherited disorder where the bones harden, becoming denser than normal. Bone growth is a balance between osteoblasts (cells that create bone tissue) and osteoclasts (cells that break down bone tissue). Those with osteopetrosis have a deficiency in osteoclasts and produce too much bone. Mild osteopetrosis results in slightly more brittle bones, but severe cases can lead to growth deformities, blindness, deafness and paralysis due to the extra bone interfering with nerve function. There is no known cure.

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