MICROSCAPE / SCIENCE PHOTO LIBRARY MICROSCAPE / SCIENCE PHOTO LIBRARY
Light microscopy of osteoclasts. Around a dozen osteoclasts are seen as large red stained cells with multiple nuclei. Osteoclasts are mobile cells that cling to bone surfaces (green) where they dissolve the bone matrix by secreting acids and enzymes. The site of bone dissolution is often noted as a gap between the osteoclasts and the bone matrix and is referred to as Howship's lacunae. In conjunction with osteoblast cells that constantly produce new bone, osteoclasts serve to remodel bone microanatomy and maintain a physiological balance of addition and removal of bone matrix. Osteoclasts originate from the bone marrow. Magnification x160 when printed at 10 cm.
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