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Caspase-3 and inhibitor

Caspase-3 and inhibitor

C025/1780

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Credit

LAGUNA DESIGN / SCIENCE PHOTO LIBRARY LAGUNA DESIGN / SCIENCE PHOTO LIBRARY

Caption

Apopain protein and inhibitor. Molecular model of caspase-3, also known as apopain, complexed with an inhibitor. Caspase-3 is a protease, an enzyme that cleaves proteins, that plays a role in apoptosis (programmed cell death). It causes the fragmentation of actin filaments, part of a cell's cytoskeleton, and the inactivation of the DNA repairing enzyme poly(ADP-ribose) polymerase. It also activates other caspases as part of the caspase cascade of apoptosis. Caspase-3 is the predominant caspase involved in Alzheimer's disease, processing the protein that is associated with neurone death.

Release details

Model release not required. Property release not required.

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