50.0 MB (49.0 MB compressed)
4180 x 4180 pixels
35.3 x 35.3 cm ⏐ 13.9 x 13.9 in (300dpi)
LAGUNA DESIGN / SCIENCE PHOTO LIBRARY LAGUNA DESIGN / SCIENCE PHOTO LIBRARY
Apopain protein and inhibitor. Molecular model of caspase-3, also known as apopain, complexed with an inhibitor. Caspase-3 is a protease, an enzyme that cleaves proteins, that plays a role in apoptosis (programmed cell death). It causes the fragmentation of actin filaments, part of a cell's cytoskeleton, and the inactivation of the DNA repairing enzyme poly(ADP-ribose) polymerase. It also activates other caspases as part of the caspase cascade of apoptosis. Caspase-3 is the predominant caspase involved in Alzheimer's disease, processing the protein that is associated with neurone death.
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