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Daclatasvir and NS5A in hepatitis C virus

Daclatasvir and NS5A in hepatitis C virus

C025/3270

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Credit

RAMON ANDRADE 3DCIENCIA / SCIENCE PHOTO LIBRARY RAMON ANDRADE 3DCIENCIA / SCIENCE PHOTO LIBRARY

Caption

Daclatasvir and NS5A in hepatitis C virus. Computer illustration showing molecules of the hepatitis C drug daclatasvir (blue) and an NS5A dimer (centre) in the phospholipid membrane (horizontal top and lower centre) of a hepatitis C virus (HCV). Daclatasvir inhibits nonstructural protein 5A (NS5A), which is found in the membrane of the hepatitis C virus and plays a key role in the replication of the virus, producing RNA from DNA (deoxyribonucleic acid). Recent research suggests that daclatasvir targets two steps of the viral replication process, enabling rapid decline of HCV RNA.

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