MICROSCAPE / SCIENCE PHOTO LIBRARY MICROSCAPE / SCIENCE PHOTO LIBRARY
Timeline series of histologic sections of bone growth showing endochondral ossification. A: chondrocytes and cartilage matrix (blue), B: chondrocytes enlarging and dying, C: capillary invasion, and narrow new bone collar (pink), D: osteoblasts and bone marrow precursors occupy cartilage spaces and bone collar (pink) is forming, E: cartilage matrix provides surfaces for new bone deposits and bone collar (pink) well developed, F: cartilage now replaced with new bone matrix forming spongy bone and bone marrow.
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