CAROL AND MIKE WERNER / SCIENCE PHOTO LIBRARY CAROL AND MIKE WERNER / SCIENCE PHOTO LIBRARY
Illustration showing the death of a cancer cell. An increase in CD-19 antigens on the surface of malignant B-cells marks the cells for destruction. On the left a T-cell delivers cytokines which contribute to cell death. Moving clockwise, an anti CD-19 monoclonal antibody leads to cell apoptosis. An antibody drug conjugate delivers a specific toxic drug to the cells. Compliment dependent cytotoxicity activates the membrane attack complex which causes the malignant cell to leak or explode. An antibody blocks growth factors which would otherwise increase cell growth and reproduction.
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