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67.8 x 50.8 cm ⏐ 26.7 x 20.0 in (300dpi)
DR MARK J. WINTER / SCIENCE PHOTO LIBRARY DR MARK J. WINTER / SCIENCE PHOTO LIBRARY
Lysyl oxidase enzyme molecule. Computer artwork showing the secondary structure of a subunit (monomer) of the enzyme lysyl oxidase (LOX). LOX is a dimeric (composed of two subunits) enzyme that has recently (as of 2009) been identified as a cause of cancer metastasis (the spread of cancer from its original location). Cancer metastasis is known to be responsible for ninety per cent of cancer-related deaths. LOX is produced by oxygen-starved (hypoxic) cells inside the tumour mass, which changes the structure of the extracellular matrix (ECM). The ECM normally acts as a barrier and separates different cell types within tissues, preventing cells from relocating.
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