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Computer graphics of cyclosporin molecule

Computer graphics of cyclosporin molecule

A624/0003

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Credit

EDELMANN / SCIENCE PHOTO LIBRARY. EDELMANN / SCIENCE PHOTO LIBRARY.

Caption

Computer graphics rendering of a cyclosporin molecule. Cyclosporins are a group of biologically active metabolites produced by the fungus Tolypocladium inflatum Gams (formerly known as Trichoderma polysporum). Cyclosporin A may be administered to reduce the risk of tissue rejection that might occur in organ transplants. Cyclosporin A appears to have greater specificity for T-lymphocytes than other cells, that is, it has limited cytotoxicity: many other cytotoxic drugs are effective against all active, dividing cells & have a greater general toxicity.

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