DR P. MARAZZI / SCIENCE PHOTO LIBRARY DR P. MARAZZI / SCIENCE PHOTO LIBRARY
Oral submucous fibrosis. Close-up of submucous fibrosis affecting the tongue of a 70-year-old female patient. Oral submucous fibrosis is a chronic pre-malignant (pre-cancerous) lesion in the mouth that results in progressive fibrosis (formation of excess fibrous connective tissue) of the submucosal tissues. As the disease progresses it may reach a point where jaws become rigid and the affected person is unable to open their mouth.
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