DR P. MARAZZI / SCIENCE PHOTO LIBRARY DR P. MARAZZI / SCIENCE PHOTO LIBRARY
Hand in CREST syndrome. Close-up of the swollen hand of a 69-year-old female patient with CREST syndrome. CREST is a form of scleroderma, a chronic, rheumatic autoimmune disease. It is an acronym for its five main features. Calcinosis - formation of calcium deposits in soft tissue; Raynaud's phenomenon - discolouration of the fingers and toes caused by decreased blood supply (seen here); Oesophageal motility disorder - difficulty in swallowing; Sclerodactyly - localised thickening and tightness of the skin of the fingers or toes; Telangiectasias - small dilated blood vessels near the surface of the skin or mucous membranes. The condition has been related to previous Borrelia burgdorferi bacteria infections. There is no cure.
Model release not required. Property release not required.