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Pesticide & cell

Pesticide & cell

C035/4673

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Credit

JACOPIN / BSIP / SCIENCE PHOTO LIBRARY JACOPIN / BSIP / SCIENCE PHOTO LIBRARY

Caption

Illustration of the action of pesticides on human cells, increasing the risk of non-Hodgkin's lymphoma, Parkinson's disease and prostate cancer. The first action of pesticides on B-lymphocytes is genotoxic, pesticides reach cellular DNA and cause the displacement of the Bcl2 gene (yellow) of chromosome 18 towards chromosome 14, causing an anarchic proliferation of B-lymphocytes. The second action affects NK-lymphocytes, which are specialized in eliminating abnormal cells such as mutated B-lymphocytes. Pesticides disrupt the production of molecules that usually allow abnormal cells to be eliminated; mutated B-lymphocytes proliferate anarchically as they are no longer eliminated by NK-lymphocytes.

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