DR P. MARAZZI / SCIENCE PHOTO LIBRARY DR P. MARAZZI / SCIENCE PHOTO LIBRARY
Pachyonychia congenita affecting the fingernail of a 95-year-old man. Pachyonychia congenita is a rare inherited condition that primarily affects the nails and skin. Fingernails and toenails may be thickened and abnormally shaped, and painful calluses and blisters may occur on the soles of the feet and on the palms of the hands. Other symptoms include white patches inside the mouth, bumps around the elbows, knees, and waistline, and cysts of various types. The condition is caused by genetic mutations in one of four genes that encode keratin proteins in epithelial tissues.
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