RAMON ANDRADE 3DCIENCIA / SCIENCE PHOTO LIBRARY RAMON ANDRADE 3DCIENCIA / SCIENCE PHOTO LIBRARY
Free fatty acid receptor, molecular model. The receptor is represented as coloured ribbons (centre), embedded in a cell membrane (white). Molecules are shown bound to the receptor: 1-Oleoyl-R-glycerol (upper left), the partial allosteric agonist MK-8666 (upper right) and the total allosteric agonist AgoPAM AP8 (lower centre). The free fatty acid receptor is a seven-helix membrane receptor that is expressed in insulin-producing pancreatic cells and neurons in certain brain areas. It is related to disorders related to insulin resistance such as type II diabetes. This is the GPR40 free fatty acid receptor.
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