DR MARK J. WINTER / SCIENCE PHOTO LIBRARY DR MARK J. WINTER / SCIENCE PHOTO LIBRARY
Lysyl oxidase enzyme molecule. Computer artwork showing the secondary structure of the enzyme lysyl oxidase (LOX). LOX is a homodimeric (composed of two identical subunits) enzyme that modifies collagen and elastin proteins so that they can crosslink, thus stabilising deposits of these proteins in the extracellular matrix (ECM). The ECM acts as a barrier and separates different cell types within tissues. It also provides structural support and regulates intercellular communication. This LOX enzyme is from a yeast (Pichia pastoris), and although structurally different from mammalian LOX, it is functionally the same.
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