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Skin rash on the buttocks and vulva of a 6-month-old girl with Langerhans cell histiocytosis. Langerhans cell histiocytosis (LCH), also known as granulomatosis, is characterised by an increase in histiocytes, a cell of the immune system. The histiocytes move into bone and other tissues, forming tumours and causing pain and swelling. Treatment is with chemotherapy and corticosteroids, and some patients recover fully, although some will relapse. The cause of the disease is not known.
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