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Cutaneous lesions (red scaly patches) on the knees of a 6-year-old boy with acrodermatitis enteropathica. Acrodermatitis enteropathica is a rare genetic disorder, characterized by rash around the mouth and/or the anus, hair loss, diarrhoea, and other symptoms. It is caused by mutations in the gene that encodes a membrane protein that binds zinc, preventing zinc absorption by the bowel, and resulting in deficiency symptoms. The condition is fatal if not treated with lifelong zinc supplements.
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