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Hand in porphyria. Close-up of blisters on the hand of a 45-year-old-male patient with porphyria cutanea tarda (PCT), a form of cutaneous porphyria. Porphyria is the name given to a group of disorders caused by an enzyme deficiency that leads to a build-up of porphyrin in the body. This can cause the skin to become photosensitised and burn or blister easily. PCT is the only porphyria disorder that may be caused by something other than an inherited genetic fault. Triggers include heavy drinking, some drugs, iron supplements and liver infections. Treatment depends on the enzyme involved, but may include drugs or restricting sun exposure.
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