PR. PHILIPPE VAGO, ISM / SCIENCE PHOTO LIBRARY PR. PHILIPPE VAGO, ISM / SCIENCE PHOTO LIBRARY
FISH (fluorescence in-situ hybridisation) light micrograph of the chromosomes at metaphase of cell division, in a normal cell (at left) and one with Philadelphia chromosome (translocation) in chronic myeloid leukaemia (CML). Humans have 46 chromosomes arranged in 23 pairs. Philadelphia chromosome is the result of a reciprocal translocation between chromosome 9 (red) and 22 (green); locus specific probes BCR:ABL: the fusion gene BCR/ABL generated by the translocation. Its presence is a sensitive test for this type of leukaemia.
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